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- Title
Ischemic Cardiovascular Disease in Persons with Human Immunodeficiency Virus Infection.
- Authors
David, Max H.; Hornung, Richard; Fichtenbaum, Carl J.
- Abstract
Persons with human immunodeficiency virus (HIV) infection might be at risk for ischemic cardiovascular disease (CVD). We reviewed the records of 16 HIV-infected persons with proven CVD (8 cases of angina and 8 cases of myocardial infarctions). This represents 1.7% of HIV-infected persons seen at our institution from 1 April 1999 through 25 April 2000. In comparison with 32 HIV-infected age- and sex-matched controls, case patients had more risk factors for CVD (median number of risk factors for CVD, 3 versus 1; Pless than.001), lower nadir CD4[sup+]lymphocyte counts (median, 101 cells/mm[sup3] versus 278 cells/mm[sup3]; P=.02 ), and a longer duration of prior exposure to nucleoside analogs (median, 190 weeks versus 130 weeks; P=.02). There was no difference in the duration of exposure to protease inhibitors. Ischemic CVD occurs in HIV-infected persons and appears to be most closely associated with traditional risk factors for coronary artery disease (for example, hypertension and hypercholesterolemia). Lower CD4[sup+] lymphocyte counts and duration of HIV infection might also be risk factors or markers for the development of ischemic CVD.
- Subjects
HIV-positive persons; CORONARY disease
- Publication
Clinical Infectious Diseases, 2002, Vol 34, Issue 1, p98
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/324745