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- Title
F-18 FDG- PET predicts outcomes for patients receiving total lymphoid irradiation and autologous blood stem-cell transplantation for relapsed and refractory Hodgkin lymphoma.
- Authors
Gentzler, Ryan D.; Evens, Andrew M.; Rademaker, Alfred W.; Weitner, Bing B.; Mittal, Bharat B.; Dillehay, Gary L.; Petrich, Adam M.; Altman, Jessica K.; Frankfurt, Olga; Variakojis, Daina; Singhal, Seema; Mehta, Jayesh; Williams, Stephanie; Kaminer, Lynne; Gordon, Leo I.; Winter, Jane N.
- Abstract
Total lymphoid irradiation ( TLI) followed by high-dose chemotherapy and autologous haematopoietic stem cell transplant ( aHSCT) is an effective strategy for patients with relapsed/refractory classical Hodgkin lymphoma ( HL). We report outcomes for patients with relapsed/refractory HL who received TLI followed by high-dose chemotherapy and aHSCT. Pre-transplant fludeoxyglucose positron emission tomography ( FDG- PET) studies were scored on the 5-point Deauville scale. Of 51 patients treated with TLI and aHSCT, 59% had primary refractory disease and 63% had active disease at aHSCT. The 10-year progression-free survival ( PFS) and overall survival ( OS) for all patients was 56% and 54%, respectively. Patients with complete response ( CR) by PET prior to aHSCT had a 5-year PFS and OS of 85% and 100% compared to 52% and 48% for those without CR ( P = 0·09 and P = 0·007, respectively). TLI and aHSCT yields excellent disease control and long-term survival rates for patients with relapsed/refractory HL, including those with high-risk disease features. Achievement of CR with salvage therapy is a powerful predictor of outcome.
- Subjects
HODGKIN'S disease treatment; AUTOGRAFTS; STEM cell transplantation; DISEASE relapse; CANCER chemotherapy; POSITRON emission tomography
- Publication
British Journal of Haematology, 2014, Vol 165, Issue 6, p793
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.12824