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- Title
Elastic scattering spectroscopy in the head & neck.
- Authors
Upile, T.; Jerjes, W.; Howard, D.; Michaels, L.; Hopper, C.; Wright, A.
- Abstract
Objectives. To develop the a technique of optical biopsy of oral dysplastic lesions that will provide real-time diagnosis, allow in situ monitoring, and which will be feasible in the clinical environment especially for patient follow-up. Method. Ethics approval was granted. Ex-vivo specimens were evaluated to determine the optimal protocol before use in vivo. 75 spectra were obtained from 25 patients with oral leukoplakia. The spectral readings were mapped, and the area was then biopsied. Photographic images were co-registered with the histological specimen. The sensitivity and specificity of the technique was determined compared to the gold standard of histo-pathological examination of paraffin sections. Results. The sensitivity and specificity in determining dysplastic from benign conditions were 70% and 78.6% respectively at 580 nm. Conclusions. The use of Elastic Scattering Spectroscopy may aid the differentiation of normal and dysplastic mucosal lesions in the head & neck. References 1 Chung, A., Karlan, S., Lindsley, E., et al. (2006) In vivo cytometry: a spectrum of possibilities. Cytometry A. 69, 142–146 2 Dhar, A., Johnson, KS., Novelli, MR., et al. (2006) Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique. Gastrointest Endosc. 63, 257–261
- Subjects
ORAL leukoplakia; BIOPSY; TREATMENT of oral cancer; DIAGNOSIS; CLINICAL trials
- Publication
Clinical Otolaryngology, 2006, Vol 31, Issue 6, p583
- ISSN
1749-4478
- Publication type
Article
- DOI
10.1111/j.1365-2273.2006.01341_14.x