We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Mobilization of visceral adipose tissue related to the improvement in insulin sensitivity in response to physical training in NIDDM. Effects of branched-chain amino acid supplements.
- Authors
Mourier, Agnès; Gautier, Jean-François; De Kerviller, Eric; Bigard, Andrè Xavier; Villette, Jean-Marie; Garnier, Jean-Pierre; Duvallet, Alain; Guezennec, Charles Yannick; Cathelineau, Gérard; Mourier, A; Gautier, J F; De Kerviler, E; Bigard, A X; Villette, J M; Garnier, J P; Duvallet, A; Guezennec, C Y; Cathelineau, G
- Abstract
<bold>Objective: </bold>To evaluate the effects of an intense physical training program on abdominal fat distribution, glycemic control, and insulin sensitivity in patients with NIDDM and to determine whether branched-chain amino acid (BCAA) supplements influence these effects.<bold>Research Design and Methods: </bold>Twenty-four patients (ages 45 +/- 2 [mean +/- SE] years, BMI 30.2 +/- 0.9 kg/m2, HbA1c 7.9 +/- 0.3%) were randomly assigned to four groups: training plus BCAA supplement (n = 6), training plus placebo (n = 6), sedentary plus BCAA supplement (n = 6), and sedentary plus placebo (n = 6). Physical training consisted of a supervised 45-min cycling exercise at 75% of their oxygen uptake peak (VO2 peak) two times per week and an intermittent exercise one time per week for 2 months.<bold>Results: </bold>Patients who exercised increased their VO2 peak by 41% and their insulin sensitivity by 46%. Physical training significantly decreased abdominal fat evaluated by magnetic resonance imaging (umbilicus), with a greater loss of visceral adipose tissue (VAT) (48%) in comparison with the loss of subcutaneous adipose tissue (18%), but did not significantly affect body weight. The change in visceral abdominal fat was associated with the improvement in insulin sensitivity (r = 0.84, P = 0.001). BCAA supplementation had no effect on abdominal fat and glucose metabolism.<bold>Conclusions: </bold>Physical training resulted in an improvement in insulin sensitivity with concomitant loss of VAT and should be included in the treatment program for patients with NIDDM.
- Publication
Diabetes Care, 1997, Vol 20, Issue 3, p385
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.20.3.385