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- Title
Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum.
- Authors
Ke Yu; Biao Ren; Junli Wei; Caixia Chen; Jinsheng Sun; Fuhang Song; Huanqin Dai; Lixin Zhang
- Abstract
The new secondary metabolites verrucosidinol (1) and its derivative verrucosidinol acetate (2), together with a potent neurotoxin verrucosidin (3), a congener norverrucosidin (4) and a mixture of two known phytotoxic metabolites terrestric acids (5 and 6), were isolated from the marine derived fungus Penicillium aurantiogriseum. Verrucosidinol has a ring-opened ethylene oxide moiety in the polyene ?-pyrone skeleton, and verrucosidinol acetate is its acetate derivative. The chemical structures were determined by comparing with literature data and a combination of spectroscopic techniques, including high resolution mass spectrum and two-dimentional nuclear magnetic resonance spectroscopic analysis.
- Subjects
MARINE fungi; PENICILLIUM; MARINE metabolites; ACETATES; NEUROTOXIC agents; ETHYLENE oxide
- Publication
Marine Drugs, 2010, Vol 8, Issue 11, p2744
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md8112744