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- Title
Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice.
- Authors
Ming-Jia Niu; Jin-Kui Yang; Shan-Shan Lin; Xiu-Juan Ji; Li-Min Guo
- Abstract
Abstract This study aimed to investigate the role of angiotensin-converting enzyme 2 (ACE2) in regulating glucose homeostasis. Immunohistochemistry was used to investigate ACE2 expression in the pancreas. Glucose tolerance test, insulin secretion test, and insulin tolerance test were performed in age-matched male ACE2 knockout (KO) and wild-type (WT) mice. We found that ACE2 was positively expressed in the pancreas. Male ACE2 KO mice displayed a selective decrease in first-phase insulin secretion in response to glucose and a progressive impairment of glucose tolerance compared with age- and sex-matched WT mice. On the other hand, insulin sensitivity of the peripheral tissue in age-matched ACE2 KO and WT mice showed no difference. These findings suggest that ACE2 might play an important role in glucose homeostasis as well as type 2 diabetes.
- Subjects
ANGIOTENSIN converting enzyme; HOMEOSTASIS; GLUCOSE; LABORATORY mice; IMMUNOHISTOCHEMISTRY; GLUCOSE tolerance tests; INSULIN resistance
- Publication
Endocrine (1355008X), 2008, Vol 34, Issue 1-3, p56
- ISSN
1355-008X
- Publication type
Article
- DOI
10.1007/s12020-008-9110-x