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- Title
Inhaled nitric oxide (iNO) for preventing prematurity-related bronchopulmonary dysplasia (BPD): 7-year follow-up of the European Union Nitric Oxide (EUNO) trial.
- Authors
Greenough, Anne; Decobert, Fabrice; Field, David; Hallman, Mikko; Hummler, Helmut D.; Jonsson, Baldvin; Sánchez Luna, Manuel; Van Overmeire, Bart; Carnielli, Virgilio P.; Potenziano, Jim L.; Mercier, Jean-Christophe
- Abstract
Most studies of inhaled nitric oxide (iNO) for prevention of bronchopulmonary dysplasia (BPD) in premature infants have focused on short-term mortality and morbidity. Our aim was to determine the long-term effects of iNO. A 7-year follow-up was undertaken of infants entered into a multicenter, double-blind, randomized, placebo-controlled trial of iNO for prevention of BPD in premature infants born between 24 and 28 weeks plus six days of gestation. At 7 years, survival and hospital admissions since the 2-year follow-up, home oxygen therapy in the past year, therapies used in the previous month and growth assessments were determined. Questionnaires were used to compare general health, well-being, and quality of life. A total of 305 children were assessed. No deaths were reported. Rates of hospitalization for respiratory problems (6.6 vs. 10.5%, iNO and placebo group, respectively) and use of respiratory medications (6.6 vs. 9.2%) were similar. Two patients who received iNO and one who received placebo had received home oxygen therapy. There were no significant differences in any questionnaire-documented health outcomes. iNO for prevention of BPD in very premature infants with respiratory distress did not result in long-term benefits or adverse long-term sequelae. In the light of current evidence, routine use of iNO cannot be recommended for prevention of BPD in preterm infants.
- Subjects
BRONCHOPULMONARY dysplasia prevention; HOME care services; MEDICAL cooperation; NITRIC oxide; OXYGEN therapy; QUALITY of life; QUESTIONNAIRES; RESEARCH; RESPIRATORY distress syndrome; RANDOMIZED controlled trials; TREATMENT effectiveness; INHALATION administration; CHILDREN
- Publication
Journal of Perinatal Medicine, 2021, Vol 49, Issue 1, p104
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/jpm-2020-0164