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- Title
Major Structural Differences and Novel Potential Virulence Mechanisms from the Genomes of Multiple Campylobacter Species.
- Authors
Foutsi, Derrick E.; Mongodin, Emmanuel F.; Mandrell, Robert E.; Miller, William G.; Rasko, David A.; Ravel, Jacques; Brinkac, Lauren M.; Deboy, Robert T.; Parker, Craig T.; Daugherty, Sean C.; Dodson, Robert J.; Durkin, A. Scott; Ramana Madupu; Sullivan, Steven A.; Shetty, Jyoti U.; Ayodeji, Mobolanle A.; Shvartsbeyn, Alla; Schatz, Michael C.; Badger, Jonathan H.; Fraser, Claire M.
- Abstract
Sequencing and comparative genome analysis of four strains of Campylobacter including C. Ian RM21 00, C. upsaliensis RM31 95, and C. coli RM2228 has revealed major structural differences that are associated with the insertion of phage- and plasmid-like genomic islands, as well as major variations in the lipooligosaccharide complex. Poly G tracts are longer, are greater in number, and show greater variability in C. upsaliensis than in the other species. Many genes involved in host colonization, including racRiS, cadF, cdt, daB, and flagellin genes, are conserved across the species, but variations that appear to be species specific are evident for a lipooligosaccharide locus, a capsular (extracellular) polysaccharide locus, and a novel Campylobacter putative licABCD virulence locus. The strains also vary in their metabolic profiles, as well as their resistance profiles to a range of antibiotics. It is evident that the newly identified hypothetical and conserved hypothetical proteins, as well as uncharacterized two-component regulatory systems and membrane proteins, may hold additional significant information on the major differences in virulence among the species, as well as the specificity of the strains for particular hosts.
- Subjects
CAMPYLOBACTER; SPIRILLACEAE; GRAM-negative bacterial diseases; MICROBIAL virulence; PATHOGENIC microorganisms; GENOMICS
- Publication
PLoS Biology, 2005, Vol 3, Issue 1, p72
- ISSN
1544-9173
- Publication type
Article
- DOI
10.1371/journal.pbio.0030015