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- Title
Synthesis and lipid-lowering properties of novel N-(4-benzoylphenyl) pyrrole-2-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats.
- Authors
Al-Qirim, Tariq; Al Bawab, Abdel Qader; Al-Hiari, Yusuf; Ahmad, Nisreen Haj; Alwahsh, Mohammad; Al-Kouz, Sameer; Shattat, Ghassan
- Abstract
One of the main risk factors that contribute to hyperlipidaemia is atherosclerosis and coronary heart disease. Therefore, researchers turn to synthesizing new compounds with potential lipid-lowering effects to overcome this issue. In the current study, Triton WR-1339 was used to induce hyperlipidaemia in the rat's model. Moreover, we were able to synthesize, characterize, and validate a novel series of N-(4-benzoylphenyl) pyrrole-2-carboxamide derivatives; (compounds 3 and 5) and assess their potency as anti-hyperlipidemic agents. 300 mg/kg of triton WR-1339 was administered overnight intraperitoneally to fasted rats to urge hyperlipidemia and divided into five groups, control, hyperlipidemic, compounds 3-, 5-, and bezafibrate-treated rats. The pharmacological evaluation of compounds 3 and 5 at a dose of 15 mg/kg body weight showed that the elevated levels of plasma triglyceride, low-density lipoprotein cholesterol, and total cholesterol were significantly reduced after 18 hours of compounds 3 (p < 0.001) and compound 5 (p < 0.01) administration in comparison to the hyperlipidemic and control group at a given 15 mg/kg body weight dose. Moreover, it was noted that compounds 3 and 5 increased the high-density lipoproteins cholesterol levels significantly by 22% and 4.5% consecutively. Therefore, it can be concluded from these findings that N-(4-benzoylphenyl) pyrrole-2-carboxamide derivatives (3 and 5) have a definite antihyperlipidemic potential which could serve as protective agents against cardiovascular diseases and atherosclerosis.
- Subjects
ANTILIPEMIC agents; CARBOXAMIDES; LABORATORY rats
- Publication
Journal of Applied Pharmaceutical Science, 2024, Vol 14, Issue 3, p64
- ISSN
2231-3354
- Publication type
Article
- DOI
10.7324/JAPS.2024.152487