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- Title
Synthesis of <sup>15</sup>N‐labelled 3,5‐dimethylpyridine.
- Authors
Schubert, Mario; Limbach, Hans‐Heinrich; Elguero, José
- Abstract
15N‐labelled pyridines are liquid‐ and solid‐state nuclear magnetic resonance (NMR) probes for chemical and biological environments because their 15N chemical shifts are sensitive to hydrogen‐bond and protonation states. By variation of the type and number of substituents, different target pyridines can be synthesized exhibiting different pKa values and molecular volumes. Various synthetic routes have been described in the literature, starting from different precursors or modification of other 15N‐labelled pyridines. In this work, we have explored the synthesis of 15N 15N‐labelled pyridines using a two‐step process via the synthesis of alkoxy‐3,4‐dihydro‐2H‐pyran as precursor exhibiting already the desired pyridine substitution pattern. As an example, we have synthesized 3,5‐dimethylpyridine‐15N (lutidine‐15N) as demonstrated by 15N‐NMR spectroscopy. That synthesis starts from methacrolein, propenyl ether, and 15N‐labelled NH4Cl as nitrogen source.
- Subjects
MOLECULAR volume; NUCLEAR magnetic resonance; RADIOLABELING; LABELS; PROTON transfer reactions
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2019, Vol 62, Issue 14, p914
- ISSN
0362-4803
- Publication type
Article
- DOI
10.1002/jlcr.3807