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- Title
Comparative Effects of Quinapril with Enalapril in Rats with Heart Failure.
- Authors
Watanabe, Kenichi; Ma, Meilei; Wen, Juan; Tachikawa, Hitoshi; Kodama, Makoto; Aizawa, Yoshifusa; Yamaguchi, Kenichi; Takahashi, Toshihiro
- Abstract
The cardioprotective properties of angiotensin-converting enzyme (ACE) inhibitors, quinapril and enalapril were studied in a rat model of heart failure. Seventy-five rats were divided into five groups and administered quinapril or enalapril at 2 and 20 mg/kg/day (groups Q2, Q20, E2 and E20) or vehicle alone (group V, all groups n = 15). Although both ACE inhibitors improved survival rate and ventricular function in a dose-dependent manner, the left ventricular end-diastolic pressure and expression level of transforming growth factor-β1 mRNA were the lowest in group Q20. These results suggest that quinapril may confer greater protection than enalapril against injury from the renin-angiotensin system in heart failure.
- Subjects
QUINAPRIL; ACE inhibitors; TRANSFORMING growth factors; HEART failure; RENIN-angiotensin system; LABORATORY rats; PHARMACOLOGY; CLINICAL trials
- Publication
Pharmacology, 2004, Vol 71, Issue 3, p157
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000077450