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- Title
Leukocyte Adherence Inhibition Microtest for the Detection of Cell-Mediated Immunity to Tumor in Gastric Cancer Patients.
- Authors
Koyama, S.; Sakita, T.; Fukutomi, H.; Kawakita, I.; Tamura, N.
- Abstract
The reactivities of leukocytes from gastric cancer and noncancer patients to gastric tumor and normal tissue extracts were tested by the leukocyte adherence inhibition (LAI) microtest, assessing cell-mediated immunoreactivity to adenocarcinoma of the stomach. The reactivities were expressed with the LAI index. All leukocyte preparations showed low reactivities, a LAI index of less than 20%, to normal tissue extracts and only the preparations of leukocytes from cancer patients displayed high reactivities, a LAI index of more than 20%, to tumor extracts. Assuming that a patient is sensitized to gastric tumor antigen if his leukocytes respond to at least one tumor extract with a LAI index of more than 20%, approximately half of the cancer patients tested in the present study are considered to have positive cell-mediated immunoreactivity to gastric tumor antigen. Thus, the LAI microtest appears to be a simple, rapid and specific method for demonstrating cell-mediated immunity to tumor. Copyright © 1981 S. Karger AG, Basel
- Publication
Oncology, 1981, Vol 38, Issue 1, p13
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000225513