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- Title
Chemotherapy-Related Reticulate Hyperpigmentation: A Case Series and Review of the Literature.
- Authors
Masson Regnault, Marie; Gadaud, Noémie; Boulinguez, Serge; Tournier, Emilie; Lamant, Laurence; Gladieff, Laurence; Roche, Henri; Guenounou, Sarah; Recher, Christian; Sibaud, Vincent
- Abstract
<bold>Background: </bold>Inherited or acquired reticulate hyperpigmentation represents a heterogeneous group of infrequent dermatological conditions. The development of reticulate hyperpigmentation has so far been rarely reported to be associated with chemotherapeutic agents, including fluorouracil, bleomycin or a combination of cytarabine and idarubicin.<bold>Case Reports: </bold>We describe 5 cases of chemotherapy-related reticulate hyperpigmentation in patients treated with different chemotherapeutic regimens, in particular paclitaxel or cytarabine. The lesions were similar in all cases, with reticulate and/or linear hyperpigmented streaks, which were mainly located to the back and buttocks. Histology showed increased melanogenesis, which suggests a direct toxic effect of chemotherapy on melanocytes. Reflectance confocal microscopy was performed in 2 patients showing a similar pattern, with an increased amount of melanin in basal keratinocytes. These features have been compared with the available data through a literature review.<bold>Conclusion: </bold>Reticulate hyperpigmentation is an underestimated but characteristic complication of chemotherapy. Neither specific management nor discontinuation of the chemotherapeutic regimen is required.
- Publication
Dermatology (10188665), 2015, Vol 231, Issue 4, p312
- ISSN
1018-8665
- Publication type
journal article
- DOI
10.1159/000439047