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- Title
Reactions of 5-(het)aryl-1-ethyl-2(1 H )-pyrazinones with terminal arylacetylenes promoted by microwave radiation.
- Authors
Verbitskiy, E.; Cheprakova, E.; Slepuhin, P.; Pervova, M.; Samorukova, M.; Zabelina, O.; Rusinov, G.; Charushin, V.
- Abstract
The reaction of 5-(het)aryl-1-ethyl-2(1 H)-pyrazinones with terminal arylacetylenes, leading to a mixture of two isomeric 4-aryl- and 5-aryl-substituted 2(1 H)-pyridones has been investigated. The regioselectivity of this reaction has been shown on the basis of reaction mixtures study by chromato-mass spectrometry. A crystallographic investigation of the synthesized 2(1 H)-pyridones and also a forecast of their potential biological activity have been carried out.
- Subjects
PYRIDONE; MICROWAVES; IONIC liquids; CHEMICAL reactions; MASS spectrometry
- Publication
Chemistry of Heterocyclic Compounds, 2011, Vol 47, Issue 6, p710
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-011-0824-y