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- Title
Exposure to bisphenol A is associated with recurrent miscarriage.
- Authors
Mayumi Sugiura-Ogasawara; Yasuhiko Ozaki; Shin-ichi Sonta; Tsunehisa Makino; Kaoru Suzumori
- Abstract
BACKGROUND: Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities. METHODS: Serum bisphenol A, antiphospholipid antibodies (aPLs), antinuclear antibodies (ANAs), natural killer cell (NK) activity, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (311) consecutive first-trimester miscarriages and 32 healthy women with no history of live birth and infertility. Subsequent pregnancy outcome and embryonic karyotype of abortuses were examined prospectively. RESULTS: The meanSD values for bisphenol A in patients were 2.595.23ng/ml, significantly higher than the 0.770.38ng/ml found for control women (P=0.024). High exposure to bisphenol A was associated with the presence of ANAs but not hypothyroidism, hyperprolactinaemia, luteal phase defects, NK cell activity or aPLs. A high level of bisphenol A in itself did not predict subsequent miscarriage. CONCLUSION: Exposure to bisphenol A is associated with recurrent miscarriage.
- Subjects
IMMUNOGLOBULINS; MISCARRIAGE; CORPUS luteum; ENDOCRINE gynecology
- Publication
Human Reproduction, 2005, Vol 20, Issue 8, p2325
- ISSN
0268-1161
- Publication type
Article
- DOI
10.1093/humrep/deh888