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- Title
TOXICITY OF NANOFIBERS AND NANOPARTICLES OF THE SAME CHEMICAL COMPOSITION.
- Authors
Báčová, Jana; Hromádko, Luděk; Roušar, Tomáš; Macak, Jan M.
- Abstract
In this presentation, the first comprehensive toxicity study of Al2O3, SiO2, ZrO2, TiO2 and WO3 nanofibers effects in cultured epithelial A549 cells will be presented. The nanofibers were produced by centrifugal spinning from suitable spinning solutions and have an average diameter in the sub-micrometer range. At first, we characterized the nanofibers for their morphological, compositional and structural properties. Then, we estimated the biological effects of nanofibers in pulmonary epithelial A549 cells comparing them with biological effects of Al2O3, SiO2, ZrO2, TiO2 and WO3 nanoparticles. Multiwalled carbon nanotubes (MWCNT) were used as a positive control. The cells were treated with 1, 10 and 100 μg.mL-1 concentrations of a nanomaterial for 24 and 48 h. The dehydrogenase activity and glutathione levels were determined in cells as markers of cell injury. Experimental details and results of these investigations will be presented and discussed (1).
- Subjects
NANOFIBERS; NANOPARTICLES; EPITHELIAL cells
- Publication
Military Medical Science Letters / Vojenské zdravotnické Listy, 2022, Vol 91, p94
- ISSN
0372-7025
- Publication type
Abstract