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- Title
State of the Art on the Role of Staphylococcus aureus Extracellular Vesicles in the Pathogenesis of Atopic Dermatitis.
- Authors
Torrealba, Marina Passos; Yoshikawa, Fabio Seiti Yamada; Aoki, Valeria; Sato, Maria Notomi; Orfali, Raquel Leão
- Abstract
Atopic dermatitis (AD) is a chronic and relapsing inflammatory cutaneous disease. The role of host defense and microbial virulence factors in Staphylococcus aureus skin colonization, infection, and inflammation perpetuation in AD remains an area of current research focus. Extracellular vesicles (EV) mediate cell-to-cell communication by transporting and delivering bioactive molecules, such as nucleic acids, proteins, and enzymes, to recipient cells. Staphylococcus aureus spontaneously secretes extracellular vesicles (SA-derived EVs), which spread throughout the skin layers. Previous research has shown that SA-derived EVs from AD patients can trigger cytokine secretion in keratinocytes, shape the recruitment of neutrophils and monocytes, and induce inflammatory AD-type lesions in mouse models, in addition to their role as exogenous worsening factors for the disease. In this review article, we aim to examine the role of SA-derived EVs in AD physiopathology and its progression, highlighting the recent research in the field and exploring the potential crosstalk between the host and the microbiota.
- Subjects
EXTRACELLULAR vesicles; ATOPIC dermatitis; MICROBIAL virulence; SKIN diseases; PATHOGENESIS; NEUTROPHILS; MONOCYTES
- Publication
Microorganisms, 2024, Vol 12, Issue 3, p531
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms12030531