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- Title
Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We?
- Authors
Fickers, Patrick; Cheng, Hairong; Sze Ki Lin, Carol
- Abstract
Sugar alcohols and organic acids that derive from the metabolism of certain microorganisms have a panoply of applications in agro-food, chemical and pharmaceutical industries. The main challenge in their production is to reach a productivity threshold that allow the process to be profitable. This relies on the construction of efficient cell factories by metabolic engineering and on the development of low-cost production processes by using industrial wastes or cheap and widely available raw materials as feedstock. The non-conventional yeast Yarrowia lipolytica has emerged recently as a potential producer of such metabolites owing its low nutritive requirements, its ability to grow at high cell densities in a bioreactor and ease of genome edition. This review will focus on current knowledge on the synthesis of the most important sugar alcohols and organic acids in Y. lipolytica.
- Subjects
SUGAR alcohols; ORGANIC synthesis; INDUSTRIAL wastes; MANUFACTURING processes; CHEMICAL industry; ORGANIC acids
- Publication
Microorganisms, 2020, Vol 8, Issue 4, p574
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms8040574