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- Title
The ideal strategy for cervical cancer screening in Japan: Result from the Fukui Cervical Cancer Screening Study.
- Authors
Kurokawa, T.; Onuma, T.; Shinagawa, A.; Chino, Y.; Yoshida, Y.; Kobayashi, M.
- Abstract
Introduction: The aims of the Fukui Cervical Cancer Screening (FCCS) study are to determine the frequency of women with high‐risk HPV (hrHPV), whether HPV16 or HPV18 (HPV16/18), in the Japanese cancer screening population for the first time and to identify the best strategy for cervical cancer screening in Japan. Methods: This study enrolled 7584 women aged ≥25 years who were undergoing routine screening. All women underwent LBC and cobas HPV tests. Women with abnormal cytology, whether hrHPV positive or negative; women with hrHPV positivity with either normal or abnormal cytology; and women randomly selected from women with normal cytology and negative hrHPV negative were referred for colposcopy. Results: The prevalences of hrHPV positivity and HPV16/18 positivity were 6.8% and 1.7%, respectively. The baseline data from the FCCS study showed that the combination of HPV tests and cytology was more sensitive than cytology with respect to the detection of intraepithelial neoplasia grade 2 or worse. However, the specificity (94.1%) of the co‐testing strategy that required all women with abnormal cytology or hrHPV positivity to be referred for colposcopy was much lower than that (97.8%) of cytology. The sensitivity and specificity of the co‐testing strategy that required only women with abnormal cytology or HPV16/18 positivity to undergo colposcopy were 85.5% and 97.0%, respectively. Conclusion: The baseline data from the FCCS study suggest that a cervical cancer screening strategy in which only women with abnormal cytology or HPV16/18 positivity undergo colposcopy offers a more balanced sensitivity and specificity than other strategies.
- Subjects
JAPAN; CERVICAL cancer; MEDICAL care; PAPILLOMAVIRUSES; CYTOLOGY; POPULATION
- Publication
Cytopathology, 2018, Vol 29, Issue 4, p361
- ISSN
0956-5507
- Publication type
Article
- DOI
10.1111/cyt.12576