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- Title
Regulation of type II collagen expression by cyclin-dependent kinase 6, cyclin D1, and p21 in articular chondrocytes.
- Authors
Hwang, Sang-Gu; Song, Sung-Min; Kim, Jeong-Ran; Park, Chun-Shik; Song, Woo-Keun; Chun, Jang-Soo
- Abstract
This study examined whether cell cycle regulatory proteins, such as cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors, regulate type II collagen expression and mediate interlukin-1 (IL-1β)-induced suppression of type II collagen expression in articular chondrocytes. IL-1β inhibited type II collagen expression, but activated CDK6. Ectopic expression of CDK2 did not alter type II collagen expression. However, overexpression of CDK6 inhibited type II collagen expression, whereas inhibition of CDK6 activity blocked IL-1β-induced suppression of type II collagen expression. IL-1β upregulated the expression of cyclin D1, which is known to activate CDK6. In turn, overexpression of cyclin D1 suppressed type II collagen expression. In contrast to cyclin D1, IL-1β triggered down-regulation of the CDK inhibitor, p21. Overexpression of p21 blocked IL-1β- or CDK6-induced suppression of type II collagen expression. Our results collectively indicate that CDK6/cyclin D1/p21 complex regulates type II collagen expression in articular chondrocytes. IUBMB Life, 59: 90-98, 2007
- Subjects
CARTILAGE cells; CYCLIN-dependent kinases; INTERLEUKINS; COLLAGEN; CYCLINS; CELL cycle
- Publication
IUBMB Life, 2007, Vol 59, Issue 2, p90
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1080/15216540701245022