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- Title
Identification of differentially expressed genes in matched formalin-fixed paraffin-embedded primary and metastatic melanoma tumor pairs.
- Authors
Jewell, Rosalyn; Mitra, Angana; Conway, Caroline; Iremonger, James; Walker, Christy; de Kort, Floor; Cook, Martin; Boon, Andy; Speirs, Valerie; Newton-Bishop, Julia
- Abstract
The article discusses a pilot study to assess the feasibility of using cDNA-mediated annealing, selection, extension, and ligation (DASL) assay to identify differentially expressed genes in primaries and extremely small formalin-fixed paraffin-embedded (FFPE) sentinel node biopsy (SNB) samples. The lower limits of sample volume that can be used to generate gene expression data using the assay is cited. It also shows that very small FFPE SNB samples can be used for gene expression analysis.
- Subjects
PILOT projects; FIRE assay; GENE expression; SENTINEL lymph nodes; BIOPSY; GENES
- Publication
Pigment Cell & Melanoma Research, 2012, Vol 25, Issue 2, p284
- ISSN
1755-1471
- Publication type
Article
- DOI
10.1111/j.1755-148X.2011.00965.x