We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
XPD Gene rs13181 Polymorphism and DNA Damage in Human Lymphocytes.
- Authors
Wlodarczyk, Marta; Nowicka, Grazyna
- Abstract
Genetic heterogeneity influencing enzyme activity may change the capacity to repair DNA damage induced by environmental and endogenous factors. This study aims to assess the impact of Lys751Gln (A/C) polymorphism in the XPD gene, encoding an enzyme involved in the nucleotide excision repair pathway, on individual DNA damage. The DNA damage in human lymphocytes (% DNA in the tail) was quantified by means of single-cell gel electrophoresis. Baseline levels of DNA damage significantly differ between AA homozygotes and carriers of the C allele, and the observed differences were not related to age, gender, or smoking status. It seems that the AA variant is associated with enhanced protection against oxidative DNA damage.
- Subjects
GENETIC polymorphisms; DNA damage; LYMPHOCYTES; ENZYME kinetics; DNA repair; GEL electrophoresis
- Publication
Biochemical Genetics, 2012, Vol 50, Issue 11/12, p860
- ISSN
0006-2928
- Publication type
Article
- DOI
10.1007/s10528-012-9526-0