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- Title
Cross-cultural Adaptation and Validation of the Medication Regimen Complexity Index Adapted to Spanish.
- Authors
Saez de la Fuente, Javier; Such Diaz, Ana; Cañamares-Orbis, Irene; Ramila, Estela; Izquierdo-Garcia, Elsa; Esteban, Concepcion; Escobar-Rodríguez, Ismael
- Abstract
<bold>Background: </bold>The most widely used validated instrument to assess the complexity of medication regimens is the Medication Regimen Complexity Index (MRCI).<bold>Objective: </bold>This study aimed to translate, adapt, and validate a reliable version of the MRCI adapted to Spanish (MRCI-E).<bold>Methods: </bold>The cross-cultural adaptation process consisted of an independent translation by 3 clinical pharmacists and a backtranslation by 2 native English speakers. A reliability analysis was conducted on 20 elderly randomly selected patients. Two clinical pharmacists calculated the MRCI-E from discharge treatments and 2 months later. For the validity analysis, the sample was augmented to 60 patients. Convergent validity was assessed by analyzing the correlation between the number of medications; discriminant validity was stratified by gender; and predictive validity was determined by analyzing the ability to predict readmission and mortality at 3 and 6 months.<bold>Results: </bold>The MRCI-E retained the original structure of 3 sections. The reliability analysis demonstrated an excellent internal consistency (Cronbach's α=0.83), and the intraclass correlation coefficient exceeded 0.9 in all cases. The correlation coefficient with the number of medications was 0.883 ( P<0.001). No significant differences were found when stratified by gender (3.6; 95%CI=-2.9 to 10.2; P=0.27). Patients who were readmitted at 3 months had a higher MRCI-E score (10.7; 95%CI=4.4 to 17.2; P=0.001). The differences remained significant in patients readmitted at 6 months, but differences in mortality were not detected.<bold>Conclusions: </bold>The MRCI-E retains the reliability and validity of the original index and provides a suitable tool to assess the complexity of medication regimens in Spanish.
- Subjects
COMPARATIVE studies; DRUGS; RESEARCH methodology; MEDICAL cooperation; MEDICAL protocols; PHARMACISTS; PSYCHOMETRICS; RESEARCH; RESEARCH evaluation; ETHNOLOGY research; EVALUATION research; DISCHARGE planning
- Publication
Annals of Pharmacotherapy, 2016, Vol 50, Issue 11, p918
- ISSN
1060-0280
- Publication type
journal article
- DOI
10.1177/1060028016656385