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- Title
Molecular Genetic Analysis of the ABO Blood Group System: 4. Another Type of O Allele.
- Authors
Yamamoto, Fumi-ichiro; McNeill, Patricia D.; Yamamoto, Miyako; Hakomori, Sen-itiroh; Bromilow, Imelda M.; Duguid, Jennifer K. M.
- Abstract
We have encountered an allele which seems to be another type of O allele at the human histo-blood group ABO locus. We have determined the nucleotide sequence of this allele over the coding region in the last two coding exons. This allele does not possess the single-nucleotide deletion found common among all the O alleles previously analyzed. Compared with A allele, this allele has three nucleotide substitutions resulting in two amino acid substitutions. The introduction of these amino acid substitutions into the A transferase expression construct apparently abolished the enzymatic activity of A transferase.
- Publication
Vox Sanguinis, 1993, Vol 64, Issue 3, p175
- ISSN
0042-9007
- Publication type
Article
- DOI
10.1111/j.1423-0410.1993.tb05158.x