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- Title
Effects of a Formula Containing Two Types of Prebiotics, Bifidogenic Growth Stimulator and Galacto-oligosaccharide, and Fermented Milk Products on Intestinal Microbiota and Antibody Response to Influenza Vaccine in Elderly Patients: A Randomized Controlled Trial
- Authors
Shinya Nagafuchi; Taketo Yamaji; Akihiro Kawashima; Yukiko Saito; Takeshi Takahashi; Takayuki Yamamoto; Mitsuo Maruyama; Hiroyasu Akatsu
- Abstract
We investigated the effect of a formula containing two different prebiotics (bifidogenic growth stimulator and galacto-oligosaccharide) and fermented milk products on intestinal microbiota and antibody responses to an influenza vaccine in enterally fed elderly in-patients. Patients were administered either formula containing prebiotics and fermented milk products (group F: n = 12, 79.9 ± 9.5 years old) or standard formula (group C: n = 12, 80.7 ± 10.1 years old) via percutaneous endoscopic gastrostomy during a 14-week intervention period. Subjects were immunized with an influenza vaccine (A/H1N1, A/H3N2, and B) at week 4 of the intervention. Blood biochemical indices, intestinal bacteria populations and antibody titers were analyzed. Bifidobacterium counts increased significantly in group F compared with group C. The enhanced antibody titers against A/H1N1 were maintained in group F for a longer period compared with group C. The titers against A/H3N2 were unchanged between both groups, and those against B were significantly lower in group F than in group C, although few subjects had seroprotective titers against A/H3N2 and B. These results suggest that administration of the formula containing prebiotics and fermented milk products may maintain antibody titers for longer periods through the improvement of intestinal microbiota.
- Subjects
EXOCRINE secretions; HEMAGGLUTINATION tests; BIFIDOBACTERIUM; FLU vaccine efficacy; DEVELOPMENTAL biology; GUT microbiome
- Publication
Pharmaceuticals (14248247), 2015, Vol 8, Issue 2, p351
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph8020351