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- Title
Covalently-linked hyaluronan promotes bone formation around Ti implants in a rabbit model.
- Authors
Morra, Marco; Cassinelli, Clara; Cascardo, Giovanna; Fini, Milena; Giavaresi, Gianluca; Giardino, Roberto
- Abstract
The goal of this study was the in vivo evaluation of nanoporous titanium (Ti) implants bearing a covalently linked surface hyaluronan (HA) layer. Implant surface topography and surface chemistry were previously evaluated by scanning electron micorscopy and X-ray photoelectron spectroscopy. Results showed that the surface modification process did not affect surface topography, yielding a homogeneously HA-coated nanotextured implant surface. In vivo evaluation of implants in both cortical and trabecular bone of rabbit femurs showed a significant improvement of both bone-to-implant contact and bone ingrowth at HA-bearing implant interfaces at 4 weeks. The improvement in osteointegration rate was particularly evident in the marrow-rich trabecular bone (bone-to-implant contact: control 22.5%; HA-coated 69.0%, p < 0.01). Mechanical testing (push-out test) and evaluation of interfacial bone microhardness confirmed a faster bone maturation around HA-coated implants (Bone Maturation Index: control 79.1%; HA-coated 90.6%, p < 0.05). Suggestions based on the biochemical role of HA are presented to account for the observed behavior. Published by Wiley Periodicals, Inc. J Orthop Res 27: 657-663, 2009
- Subjects
ORTHOPEDICS; HYALURONIC acid; BONE growth; OSSEOINTEGRATION; ORTHOPEDIC implants
- Publication
Journal of Orthopaedic Research, 2009, Vol 27, Issue 5, p657
- ISSN
0736-0266
- Publication type
Article
- DOI
10.1002/jor.20797