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- Title
Dynamics of Bile Acid Profiles, GLP-1, and FGF19 After Laparoscopic Gastric Banding.
- Authors
Thöni, Veronika; Pfister, Alexandra; Melmer, Andreas; Enrich, Barbara; Salzmann, Karin; Kaser, Susanne; Lamina, Claudia; Ebenbichler, Christoph F; Hackl, Hubert; Tilg, Herbert; Moschen, Alexander R
- Abstract
<bold>Context: </bold>An increase of bile acids (BAs), fibroblast growth factor 19 (FGF19), and glucagon-like peptide 1 (GLP-1) has been implicated in metabolic improvements after Roux-en-Y gastric bypass and vertical sleeve gastrectomy. However, data are still conflicting regarding their role after laparoscopic adjustable gastric banding (LAGB).<bold>Objective: </bold>To assess the fasting BA, FGF19, and GLP-1 concentrations in plasma before and after LAGB and to test for correlations with immunometabolic parameters. Furthermore, hepatic farnesoid X receptor (FXR) expression and regulation of FXR-dependent genes were analyzed.<bold>Design and Setting: </bold>Observational study at the University Hospital Innsbruck.<bold>Patients: </bold>Twenty obese patients.<bold>Interventions: </bold>Fasting plasma samples were taken before, 3, 6, and 12 months after LAGB. Liver biopsies were obtained at surgery and after 6 months postoperatively.<bold>Main Outcome Measures: </bold>BA profiles, GLP-1 and FGF19 levels, hepatic FXR expression and regulation of FXR target genes were determined.<bold>Results: </bold>Total, conjugated, and secondary BAs transiently increased 3 months after LAGB (P < 0.01). Only one BA, glycolithocholic acid sulfate, remained significantly elevated throughout the whole follow-up period (P < 0.05). GLP-1 had increased transiently 3 months after surgery (P < 0.01), whereas FGF19 levels increased continuously (P < 0.05). Insulin, homeostasis model assessment index, C-reactive protein, FGF19, and GLP-1 correlated positively with different BAs. No differences were seen in hepatic FXR expression and FXR-regulated genes.<bold>Conclusions: </bold>Our study results, not only identified LAGB-induced changes in BAs and BA-induced hormones, but also revealed associations between changes in BA profile with GLP-1 and FGF19.
- Subjects
C-reactive protein; CELL receptors; GENES; GROWTH factors; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN resistance; LAPAROSCOPY; LIVER; BARIATRIC surgery; POLYMERASE chain reaction; STEROIDS; GLUCAGON-like peptide 1; MORBID obesity
- Publication
Journal of Clinical Endocrinology & Metabolism, 2017, pN.PAG
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2017-00235