We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Associations of serum 25-hydroxyvitamin D concentrations with quality of life and self-rated health in an older population.
- Authors
Rafiq, R; Swart, K M A; van Schoor, N M; Deeg, D J; Lips, P; de Jongh, R T
- Abstract
<bold>Context: </bold>Vitamin D deficiency has been associated with impaired physical functioning, depression, and several chronic diseases and might thereby affect quality of life and self-rated health.<bold>Objective: </bold>The aim of this study was to assess relationships of serum 25-hydroxyvitamin D [25(OH)D] with quality of life and self-rated health and to examine whether physical performance, depressive symptoms, and number of chronic diseases mediate these relationships.<bold>Design: </bold>We analyzed data from the Longitudinal Aging Study Amsterdam, an ongoing population-based cohort study of older Dutch individuals.<bold>Main Outcome Measures: </bold>Serum 25(OH)D was classified into the following categories: less than 25, 25-50, and 50 nmol/L or greater. We assessed quality of life (QOL) using the Short Form-12 Health Survey (SF-12; n = 862) and self-rated health (SRH) with a single question, dichotomized into good vs poor SRH (n = 1248).<bold>Results: </bold>Individuals with serum 25(OH)D less than 25 nmol/L scored lower on the physical component score of the SF-12 and had a lower odds on good SRH score compared with individuals with serum 25(OH)D greater than 50 nmol/L (β (95% confidence interval) -3.9 (-6.5 to -1.3) for SF-12, and odds ratio [95% confidence interval) 0.50 (0.33-0.76) for SRH]. Physical performance, depressive symptoms, and the number of chronic diseases were associated with vitamin D status, QOL, and SRH. Adding all these potential mediators to regression models attenuated associations of 25(OH)D less than 25 nmol/L with QOL with 78% and SRH with 32%.<bold>Conclusion: </bold>Lower 25(OH)D status is related to lower scores on QOL and SRH. A large part of the association with QOL can statistically be explained by physical performance, depressive symptoms, and the number of chronic diseases.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2014, Vol 99, Issue 9, p3136
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2013-4431