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- Title
How Do We Know What We Are Missing? Loss of Signaling through CD148 Drives Fibroblast Activation in Pulmonary Fibrosis.
- Authors
Redente, Elizabeth F.
- Abstract
The article presents the discussion on examination of signaling pathways associated with idiopathic pulmonary fibrosis (IPF). Topics include increasing clinical trials dedicated to IPF and other fibrosing interstitial lung diseases and the approval of two antifibrotic therapies; glycosaminoglycan chains with matrix proteins, cytokines, growth factors, and their receptors; and promoting the internalization of TGFbR1 and reducing cellular apoptosis.
- Subjects
JAK-STAT pathway; IDIOPATHIC pulmonary fibrosis; CLINICAL trials; LUNG diseases; APOPTOSIS
- Publication
American Journal of Respiratory & Critical Care Medicine, 2021, Vol 204, Issue 3, p249
- ISSN
1073-449X
- Publication type
editorial
- DOI
10.1164/rccm.202103-0737ED