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- Title
HBsAg and HBeAg in the prediction of a clinical response to peginterferon α-2b therapy in Chinese HBeAg-positive patients.
- Authors
Song Yang; Huichun Xing; Yuming Wang; Jinlin Hou; Duande Luo; Qing Xie; Qin Ning; Hong Ren; Huiguo Ding; Jifang Sheng; Lai Wei; Shijun Chen; Xiaoling Fan; Wenxiang Huang; Chen Pan; Zhiliang Gao; Jiming Zhang; Boping Zhou; Guofeng Chen; Mobin Wan
- Abstract
Background: This study aimed to evaluate the predictive values of hepatitis B e antigen (HBeAg) and hepatitis B surface antigen (HBsAg) levels in 171 Chinese patients with chronic hepatitis B who received a 48-week course of pegylated interferon alfa-2b therapy at 1.5 mcg/kg. Methods: HBsAg, HBeAg, and hepatitis B virus (HBV) DNA levels were measured at baseline and weeks 12, 24, 48, and 72. Clinical responses were defined as a combined response (CR, HBeAg seroconversion [sustained response, SR] combined with HBV DNA level <2,000 IU/mL at week 72). The positive predictive value and negative predictive value were calculated for HBsAg alone and/or combined with HBeAg and HBV DNA at weeks 12 and 24. Results: Of 171 patients included, 58 (33.9%) achieved a SR. Of patients who achieved a SR, 33 (56.9%) achieved a CR. Totally 19.3% (33/171) patients achieved CR and 80.7% (138/171) patients did not. Patients with HBsAg <1500 IU/mL at week 12 had a 47.4% chance of achieving an off-treatment SR and patients with a HBsAg decrease >1.5 logIU/mL at week 12 had a 54.5% chance. Patients with HBsAg >20,000 IU/mL at weeks 12 and 24 had a 93.8 and 100.0% chance, respectively, of not achieving a CR. An HBsAg level or changes at weeks 12 and 24, combined with HBeAg or HBV DNA, increased the chance for a SR and CR. Conclusions: On-treatment HBsAg quantification, alone or in combination with HBeAg or HBV DNA, predicted off-treatment SR and CR after 48 weeks of PEG-IFNa-2b therapy, and thus, may guide clinicians in making a therapeutic decision to continue or terminate the therapy.
- Subjects
THERAPEUTIC use of interferons; CHINESE people; HEPATITIS B treatment; HEPATITIS associated antigen; SEROCONVERSION; DISEASES
- Publication
Virology Journal, 2016, Vol 13, Issue 1, p1
- ISSN
1743-422X
- Publication type
Article
- DOI
10.1186/s12985-016-0640-1