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- Title
Combination of available topical beta-blockers and antibiotic ointment for epidermal growth factor receptor tyrosine kinase inhibitor-induced paronychia and pseudopyogenic granulomas in Taiwan.
- Authors
Liu, Hui-Lin; Chuang, Cheng-Hao; Chen, Chin-Ling; Wei, Po-Ju; Yang, Chih-Jen
- Abstract
Background: Painful paronychia and pseudopyogenic granuloma (PG) are common adverse drug reactions (ADRs) associated with the use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) to treat non-small cell lung cancer (NSCLC). Multiple local management approaches have been tested with unsatisfactory results. We have introduced an occlusion therapy technique through which available topical drugs for longer than 2 years. Methods: Based on the cancer registry and case management system of our hospital, from July 2019 to July 2020, we retrospectively enrolled patients with NSCLC who were treated with EGFR-TKIs and received applications of 0.5% timolol ophthalmic solution (TIMOPTOL XE 0.5%®) combined with a neomycin/tyrothricin ointment (Biomycin ®) using the occlusion method to treat paronychia or PG. Results: A total of 22 patients were enrolled, with a mean age of 66.5 years, most of whom were women (72.7%). Periungual lesion-related pain was reported by all patients, and periungual bleeding and PG were reported in 14% (3/22) and 64% (14/22) of patients, respectively. After the occlusion therapy application of timolol ophthalmic solution combined with neomycin/tyrothricin ointment twice daily, the overall response rate was 83.3%, including complete response in 18% (4/22) of cases and partial response in 68% (15/22) of cases. Conclusion: We presented an occlusion method using available topical beta-blockers and antibiotic ointment for EGFR-TKI-induced paronychia and PG in Taiwan. The result is favorable. Further randomized control trial is urgent to validate our findings
- Subjects
TAIWAN; ANTIBIOTICS; REPORTING of diseases; COMBINATION drug therapy; EPIDERMAL growth factor receptors; PARONYCHIA; RETROSPECTIVE studies; ACQUISITION of data; NEOMYCIN; ADRENERGIC beta blockers; PROTEIN-tyrosine kinase inhibitors; TREATMENT effectiveness; OPHTHALMIC drugs; MEDICAL records; DESCRIPTIVE statistics; TIMOLOL maleate
- Publication
Journal of Oncology Pharmacy Practice, 2023, Vol 29, Issue 6, p1374
- ISSN
1078-1552
- Publication type
Article
- DOI
10.1177/10781552221122051