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- Title
Systemic exposure following intravitreal administration of therapeutic agents: an integrated pharmacokinetic approach. 1. THR-149.
- Authors
Vanhove, Marc; Noppen, Bernard; Wagner, Jean-Marc; Van Bergen, Tine; Barbeaux, Philippe; Stitt, Alan W.
- Abstract
Intravitreal (IVT) injection of pharmacological agents is an established and widely used procedure for the treatment of many posterior segment of the eye diseases. IVT injections permit drugs to reach high concentrations in the retina whilst limiting systemic exposure. Beyond the risk of secondary complications such as intraocular infection, the potential of systemic adverse events cannot be neglected. Therefore, a detailed understanding of the rules governing systemic exposure following IVT drug administration remains a prerequisite for the evaluation and development of new pharmacological agents intended for eye delivery. We present here a novel mathematical model to describe and predict circulating drug levels following IVT in the rabbit eye, a species which is widely used for drug delivery, pharmacokinetic, and pharmacodynamic studies. The mathematical expression was derived from a pharmacokinetic model that assumes the existence of a compartment between the vitreous humor compartment itself and the systemic compartment. We show that the model accurately describes circulating levels of THR-149, a plasma kallikrein inhibitor in development for the treatment of diabetic macular edema. We hypothesize that the model based on the rabbit eye has broader relevance to the human eye and can be used to analyze systemic exposure of a variety of drugs delivered in the eye.
- Subjects
POSTERIOR segment (Eye); PHARMACOKINETICS; VITREOUS humor; MACULAR edema; DRUG utilization; MACULA lutea
- Publication
Journal of Pharmacokinetics & Pharmacodynamics, 2021, Vol 48, Issue 6, p825
- ISSN
1567-567X
- Publication type
Article
- DOI
10.1007/s10928-021-09773-w