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- Title
Prospect of Thiazole‐based γ‐Peptide Foldamers in Enamine Catalysis: Exploration of the Nitro‐Michael Addition.
- Authors
Aguesseau‐Kondrotas, Julie; Simon, Matthieu; Legrand, Baptiste; Bantigniès, Jean‐Louis; Kang, Young Kee; Dumitrescu, Dan; Van der Lee, Arie; Campagne, Jean‐Marc; de Figueiredo, Renata Marcia; Maillard, Ludovic T.
- Abstract
As three‐dimensional folding is prerequisite to biopolymer activity, complex functions may also be achieved through foldamer science. Because of the diversity of sizes, shapes and folding available with synthetic monomers, foldamer frameworks enable a numerous opportunities for designing new generations of catalysts. We herein demonstrate that heterocyclic γ‐peptide scaffolds represent a versatile platform for enamine catalysis. One central feature was to determine how the catalytic activity and the transfer of chiral information might be under the control of the conformational behaviours of the oligomer.
- Subjects
CATALYSIS; CATALYTIC activity; PROSPECTING; HELICAL structure; KNOWLEDGE transfer; METALLOPORPHYRINS
- Publication
Chemistry - A European Journal, 2019, Vol 25, Issue 30, p7396
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201901221