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- Title
Fluorescent Molecular Rotors for Viscosity Sensors.
- Authors
Lee, Seung‐Chul; Heo, Jeongyun; Woo, Hee Chul; Lee, Ji‐Ah; Seo, Young Hun; Lee, Chang‐Lyoul; Kim, Sehoon; Kwon, O‐Pil
- Abstract
Abstract: Fluorescent molecular rotors (FMRs) can act as viscosity sensors in various media including subcellular organelles and microfluidic channels. In FMRs, the rotation of rotators connected to a fluorescent π‐conjugated bridge is suppressed by increasing environmental viscosity, resulting in increasing fluorescence (FL) intensity. In this minireview, we describe recently developed FMRs including push–pull type π‐conjugated chromophores, meso‐phenyl (borondipyrromethene) (BODIPY) derivatives, dioxaborine derivatives, cyanine derivatives, and porphyrin derivatives whose FL mechanism is viscosity‐responsive. In addition, FMR design strategies for addressing various issues (e.g., obtaining high FL contrast, internal FL references, and FL intensity‐contrast trade‐off) and their biological and microfluidic applications are also discussed.
- Subjects
MEASUREMENT of viscosity; VISCOSITY solutions; FLUORESCENCE; CHROMOPHORES; ROTORS
- Publication
Chemistry - A European Journal, 2018, Vol 24, Issue 52, p13706
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201801389