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- Title
Modulation of AMPA receptor unitary conductance by synaptic activity.
- Authors
Benke, Tim A.; Luthi, Andreas; Isaac, John T. R.; Collingridge, Graham L.
- Abstract
Reports on experiments which show that the induction of long-term potentiation (LTP) in the CA1 region of the hippocampus is often associated with an increase in single-channel conductance of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepopionate receptors (AMPA). How the elementary channel properties can be rapidly modified by synaptic activity and provide an insight into one molecular mechanism by which glutamatergic synapses can alter their strength.
- Subjects
HIPPOCAMPUS (Brain); SYNAPSES; ELECTRONICS
- Publication
Nature, 1998, Vol 393, Issue 6687, p793
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/31709