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- Title
Salmonella typhi uses CFTR to enter intestinal epithelial cells.
- Authors
Pier, Gerald B.; Grout, Martha; Zaidi, Tanweer; Meluleni, Gloria; Mueschenborn, Simone S.; Banting, George; Ratcliff, Rosemary; Evans, Martin J.; Colledge, William H.
- Abstract
Investigates the possibility that typhoid fever could be a disease where homozygous mutations in the fibrosis transmembrane conductance regulator (CFTR) occurs. How in the heterozygous state, increased resistance to infectious diseases may maintain mutmant CFTR alleles at high levels in selected population; Evidence indicating that Salmonella typhi uses CFTR for entry into epithelial cells; The conclusion of the research.
- Subjects
SALMONELLA typhi; GENETIC mutation
- Publication
Nature, 1998, Vol 393, Issue 6680, p79
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/30006