We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Germline-encoded recognition of diverse glycolipids by natural killer T cells.
- Authors
Scott-Browne, James P; Matsuda, Jennifer L; Mallevaey, Thierry; White, Janice; Borg, Natalie A; McCluskey, James; Rossjohn, Jamie; Kappler, John; Marrack, Philippa; Gapin, Laurent
- Abstract
Natural killer T cells expressing 'invariant' T cell receptor α-chains (TCRα chains) containing variable (V) and joining (J) region Vα14-Jα18 (Vα14i) rearrangements recognize both endogenous and microbial glycolipids in the context of CD1d. How cells expressing an invariant TCRα chain and a restricted set of TCRβ chains recognize structurally diverse antigens is not clear. Here we show that a Vα14i TCR recognized many α-linked glycolipids by means of a 'hot-spot' of germline-encoded amino acids in complementarity-determining regions 3α, 1α and 2β. This hot-spot did not shift during the recognition of structurally distinct antigens, suggesting that the Vα14i TCR functions as a pattern-recognition receptor, conferring on natural killer T cells the ability to sense and respond in an innate way to pathogens displaying antigenic α-linked glycolipids.
- Publication
Nature Immunology, 2007, Vol 8, Issue 10, p1105
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1510