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- Title
Surface-bound chemokines capture and prime T cells for synapse formation.
- Authors
Friedman, Rachel S.; .Jacobelli, Jordan; Krummel, Matthew F.
- Abstract
T cell activation in vivo occurs in a lymphoid milieu that presents chemotactic and T cell receptor signals concurrently. Here we demonstrate that T cell zone chemokines such as CCL21 are bound to the surface of lymph node dendritic cells. Contact with antigen-presenting cells bearing chemokines costimulated T cells by a previously unknown two-step contact mechanism. T cells initially formed an antigen-independent 'tethered' adhesion on chemokine-bearing antigen-presenting cells. The formation of those tethers superseded T cell receptor signaling and immunological synapse formation. However, chemokine-tethered T cells were hyper-responsive to subsequent contacts with antigen-presenting cells. Thus, T cells are costimulated 'in trans' and sequentially after initial engagement with their chemokine-rich environment.
- Subjects
CHEMOKINES; T cell receptors; SYNAPSES; DENDRITIC cells; ANTIGENS; LYMPH nodes; IMMUNOLOGY
- Publication
Nature Immunology, 2006, Vol 7, Issue 10, p1101
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1384