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- Title
PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan.
- Authors
Kaneko, Takashi; Yano, Tamaki; Aggarwal, Kamna; Jae-Hong Lim; Ueda, Kazunori; Oshima, Yoshiteru; Peach, Camilla; Erturk-Hasdemir, Deniz; Goldman, William E.; Byung-Ha Oh; Kurata, Shoichiro; Silverman, Neal
- Abstract
Drosophila rely entirely on an innate immune response to combat microbial infection. Diaminopimelic acid–containing peptidoglycan, produced by Gram-negative bacteria, is recognized by two receptors, PGRP-LC and PGRP-LE, and activates a homolog of transcription factor NF-κB through the Imd signaling pathway. Here we show that full-length PGRP-LE acted as an intracellular receptor for monomeric peptidoglycan, whereas a version of PGRP-LE containing only the PGRP domain functioned extracellularly, like the mammalian CD14 molecule, to enhance PGRP-LC-mediated peptidoglycan recognition on the cell surface. Interaction with the imd signaling protein was not required for PGRP-LC signaling. Instead, PGRP-LC and PGRP-LE signaled through a receptor-interacting protein homotypic interaction motif–like motif. These data demonstrate that like mammals, drosophila use both extracellular and intracellular receptors, which have conserved signaling mechanisms, for innate immune recognition.
- Subjects
DROSOPHILA; GRAM-negative bacteria; TRANSCRIPTION factors; PEPTIDOGLYCANS; IMMUNE response
- Publication
Nature Immunology, 2006, Vol 7, Issue 7, p715
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1356