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- Title
Interleukin‐25: New perspective and state‐of‐the‐art in cancer prognosis and treatment approaches.
- Authors
Gowhari Shabgah, Arezoo; Amir, Azwar; Gardanova, Zhanna R.; Olegovna Zekiy, Angelina; Thangavelu, Lakshmi; Ebrahimi Nik, Maryam; Ahmadi, Majid; Gholizadeh Navashenaq, Jamshid
- Abstract
Cancer is a leading cause of death which imposes a substantial financial burden. Among the several mechanisms involved in cancer progression, imbalance of immune cell‐derived factors such as cytokines and chemokines plays a central role. IL‐25, as a member of the IL‐17 cytokine subfamily, exerts a paradoxical role in cancer, including tumor supportive and tumor suppressive. Hence, we have tried to clarify the role of IL‐25 and its receptor in tumor progression and cancer prognosis. It has been confirmed that IL‐25 exerts a tumor‐suppressive role through inducing infiltration of eosinophils and B cells into the tumor microenvironment and activating the apoptotic pathways. In contrast, the tumor‐supportive function has been implemented by activating inflammatory cascades, promoting cell cycle, and inducing type‐2 immune responses. Since IL‐25 has been dysregulated in tumor tissues and this dysregulation is involved in cancer development, its examination can be used as a tumor diagnostic and prognostic biomarker. Moreover, IL‐25‐based therapeutic approaches have shown promising results in cancer inhibition. In cancers in which IL‐25 has a tumor‐suppressive function, employing IL‐25‐enhancing approaches, such as Virulizin® and dihydrobenzofuran administration, has potentially inhibited tumor cell growth. On the other hand, in the case of IL‐25‐dependent tumor progression, using IL‐25 blocking methods, including anti‐IL‐25 antibodies, might be a complementary approach to the other anticancer agent. Collectively, it is hoped, IL‐25 might be a promising target in cancer treatment.
- Subjects
THERAPEUTICS; CANCER invasiveness; CANCER prognosis; CANCER treatment; CAUSES of death
- Publication
Cancer Medicine, 2021, Vol 10, Issue 15, p5191
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.4060