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- Title
Alternative antiandrogen therapy in patients with castration-resistant prostate cancer: A single-center experience T OKEGAWA ET AL. Alternative antiandrogen therapy.
- Authors
Okegawa, Takatsugu; Nutahara, Kikuo; Higashihara, Eiji
- Abstract
Outcomes of alternative (second-line) antiandrogen therapy in 112 patients with relapsing prostate cancer after first-line hormonal therapy were analyzed. A good response (prostate-specific antigen [PSA] decrease ≥50%) and a partial response (PSA decrease of 0-50%) by switching from bicalutamide (BCL) to flutamide (FLT) and from FLT to BCL were achieved in 35.4% (28/79) and 30.4% (24/79), and in 45.0% (9/20) and 20.0% (4/20) of cases, respectively. A good response and a partial response with the change from chlormadinone acetate (CMA) to a non-steroidal antiandrogen (FLT or BCL) and from a non-steroidal antiandrogen to CMA were obtained in 25.0% (2/8) and 37.5% (3/8), and in 20.0% (1/5) and 0% (0/5) of cases, respectively. In multivariate analyses, a second-line good response was significantly predictive of cause-specific survival from first therapy relapse to cancer death in all patients. Patients (52/112, 46.4%) with ≥30% decrease in PSA levels were associated with significantly better cause-specific survival as measured from the start of first-line treatment and first-line relapse.
- Subjects
ANTIANDROGENS; MALE reproductive organs; PROGESTATIONAL hormones; TUMOR antigens; FLUTAMIDE
- Publication
International Journal of Urology, 2010, Vol 17, Issue 11, p950
- ISSN
0919-8172
- Publication type
Article
- DOI
10.1111/j.1442-2042.2010.02620.x