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- Title
Neuroprotection in glaucoma: recent advances and clinical translation.
- Authors
Guymer, Chelsea; Wood, John PM; Chidlow, Glyn; Casson, Robert J
- Abstract
Intraocular pressure (IOP) reduction is currently the only evidence‐based treatment strategy for glaucoma. However, IOP control in some individuals is challenging. Despite optimal treatment, a significant proportion of individuals will progress, with loss of visual field, loss of driving vision and impaired quality of life. A new modality that could augment current treatment and reduce the rate of neurodegeneration to preserve vision throughout life would be a major breakthrough. A vast number of studies have reported effective neuroprotection in animal models of glaucoma; however, translation to the clinic remains a major hurdle. Herein, we explore the therapeutic advancements in non‐IOP‐dependent neuroprotection research based upon potential pathogenic mechanisms and propose strategies to improve the clinical translation of neuroprotective research in glaucoma.
- Publication
Clinical & Experimental Ophthalmology, 2019, Vol 47, Issue 1, p88
- ISSN
1442-6404
- Publication type
Article
- DOI
10.1111/ceo.13336