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- Title
Comparison of new Biomarkers in the Diagnosis of Perinatal Asphyxia.
- Authors
BOSKABADI, Hassan; ZAKERIHAMIDI, Maryam; GHAYOUR MOBARHAN, Majid; BAGHERI, Fatemeh; MORADI, Ali; BEIRAGHI TOOSI, Mehran
- Abstract
Objectives Precise and early diagnosis of neonatal asphyxia may improve outcomes. Recent studies aim to identify diagnostic biomarkers in neonates at risk for brain damage. The current study was designed to evaluate the diagnostic value of new biomarkers for neonatal asphyxia. Materials & Methods This prospective study was conducted with an available sampling of infants upper 35 weeks of gestational age, including neonates with asphyxia (case group) and healthy controls, 2014-2022, in Ghaem Hospital, Mashhad, Iran. Data collection was performed utilizing a researcher-made questionnaire, including maternal and neonatal characteristics, as well as clinical and laboratory evaluation. Serum umbilical cord levels of interleukin-6 (IL6), interleukin-1-beta (IL-1β), pro-oxidant-antioxidant balance (PAB), and heat shock protein-70 (HSP70), as well as nucleated red blood cells count (NRBC), were determined. Data were analyzed by t-test, Chi-square, receiver operating characteristic (ROC), and regression models. Results The differences in variables IL6, IL1β, PAB, NRBC/100WBC, and HSP70 were statistically significant between the two groups (in all cases, P<0.0001). In the diagnosis of asphyxia, the most sensitive marker (89%) was IL1β more than 2.39 pg/ml and HSP 70 upper than 0.23 ng/ml, while IL6 was higher than 9pg/ml, determined as the most specific marker (85%). Furthermore, a combination of HSP + PAB and IL6 + lL1b + PAB + NRBC/100WBC possesses the prediction power of 93.2% and 87.3%, respectively, for diagnosing asphyxia. Conclusion According to data analysis, the combination of new biochemical markers (NRBC count, IL6, IL1β, PAB, and HSP 70) could be a reliable marker for diagnosing infants with asphyxia.
- Subjects
IRAN; BIOMARKERS; INTERLEUKINS; UMBILICAL cord; T-test (Statistics); CHI-squared test; ASPHYXIA neonatorum; RECEIVER operating characteristic curves; EARLY diagnosis; LONGITUDINAL method
- Publication
Iranian Journal of Child Neurology, 2023, Vol 17, Issue 2, p99
- ISSN
1735-4668
- Publication type
Article
- DOI
10.22037/ijcn.v17i2.38561