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- Title
Sugar or Fat?--Metabolic Requirements for Immunity to Viral Infections.
- Authors
Shehata, Hesham M.; Murphy, Andrew J.; Lee, Man Kit Sam; Gardiner, Clair M.; Crowe, Suzanne M.; Sanjabi, Shomyseh; Finlay, David K.; Palmer, Clovis Steve
- Abstract
The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty-acid oxidation (sugar or fat) regulates the capacity of immune cells to mount robust and effective immune responses. We will also discuss how fine-tuning sugar and fat metabolism may be exploited as a novel immunotherapeutic strategy to fight viral infections or improve vaccine efficacy.
- Subjects
CELLULAR immunity; OXIDATION of fats &; oils; GLYCOLYSIS; IMMUNOLOGY; VIRUS diseases; METABOLISM
- Publication
Frontiers in Immunology, 2017, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2017.01311