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- Title
Sensitization to the psychosis-inducing effects of cocaine compared with measures of cocaine craving and cue reactivity.
- Authors
Reid, Malcolm S.; Ciplet, Debra; O'Leary, Siobhan; Branchey, Marc; Buydens‐Branchey, Laure; Angrist, Burt
- Abstract
A previous study has suggested that sensitization to the psychosis-inducing effects of cocaine may be a marker of vulnerability to relapse in cocaine addiction. In this report, cocaine-dependent subjects participating in a study on naturally occurring and cue-induced cocaine craving were interviewed about prior experience of cocaine-induced psychosis and the degree to which this effect had become more frequent or severe or had occurred at lower cumulative doses. Sensitization to cocaine-induced psychosis was negatively correlated with baseline measures of drug dependence severity and indices of cocaine craving over the preceding 24 hours but not with measures of cocaine cue reactivity.
- Subjects
COCAINE abuse; COCAINE; PATHOLOGICAL psychology; PSYCHOSES; SUBSTANCE abuse; NARCOTICS; COMPARATIVE studies; DRUG resistance; RESEARCH methodology; DOPAMINE uptake inhibitors; MEDICAL cooperation; RESEARCH; DISEASE relapse; EVALUATION research; PHARMACODYNAMICS
- Publication
American Journal on Addictions, 2004, Vol 13, Issue 3, p305
- ISSN
1055-0496
- Publication type
journal article
- DOI
10.1080/10550490490460175