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- Title
Extract of Glycyrrhiza glabra root attenuates nociception in experimental pain models: The role of BKCa channels.
- Authors
Parlar, Ali; Köprülü, Rabia Edibe Parlar; Arslan, Seyfullah Oktay; Çam, Saliha Ayşenur; Özdoğan, Fidan Pesen; Yumrutaş, Önder; Üçkardeş, Fatih; Ríos, Miguel; Martinez, José L.
- Abstract
The aim of this study was to evaluate the functional interaction of Glycyrrhiza glabra root extract (GGRE) on the large conductance Ca2+-activated K+ (BKCa) channels expressed in the peripheral nervous system by using nociception and inflammation models in rodents in vivo. Besides toxicity studies and open field tests, nociception and inflammation tests were performed on rodents. Different doses of GGRE were given orally to rats and mice. Naloxone, indomethacin, morphine, NS1619 and iberiotoxin (IbTX) were administered. GGRE had both anti-nociceptive and anti-inflammatory activity in rats and mice. GGRE exhibited an analgesic effect by decreasing the time-course of the pain threshold or reaction time in some nociceptive tests. Furthermore, GGRE reduced level of pro-inflammatory cytokines, including TNF-α and IL-1β. As a conclusion, GGRE can alleviate the pain sensation of the afferent nerves and can reduce inflammation and associated pain by activating BKCa channels and reducing the levels of TNF-α, IL1β.
- Subjects
LICORICE (Plant); PERIPHERAL nervous system; PLANT extracts; REACTION time; ACTIVATION energy; ANTI-inflammatory agents; PAIN threshold
- Publication
Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 2022, Vol 21, Issue 4, p464
- ISSN
0717-7917
- Publication type
Article
- DOI
10.37360/blacpma.22.21.4.29