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- Title
Coagulation Parameters in Wilson Disease.
- Authors
Schaefer, Mark; Weber, Laura; Gotthardt, Daniel; Seessle, Jessica; Stremmel, Wolfgang; Pfeiffenberger, Jan; Weiss, Karl Heinz
- Abstract
Background & Aims: Wilson disease (WD) is an autosomal recessive disorder of copper metabolism. Alterations of copper metabolism have been associated with changes in coagulation factors. The aim of the present study was the analysis of coagulation factors in WD patients. Methods: 100 patients attending a tertiary WD outpatient clinic were analyzed in a prospective cross sectional cohort study. Out of peripheral venous blood samples coagulation factors were assessed including: full blood count, INR, partial thromboplastin time (PTT), clotting factors II, V, VII, VIII, IX, X, XI, XII, XIII, von Willebrand factor/-antigen, fibrinogen, antithrombin III, protein S, protein C, activated protein C (APC) resistance. Subgroup analyses of the blood tests were performed for sex, initial clinical presentation, WD treatment and liver function. Results: Subgroup analysis by liver function showed decreased levels of factors II, V, VII and X. Subgroup analysis by gender or clinical course of the disease did not reveal significant coagulation changes. In patients treated with trientine significantly decreased levels of factors II, VII and antithrombin III and increased von Willebrand factor/-antigen levels were detected. Factor VIII levels were significantly reduced in patients receiving zinc. Conclusion: Although significant differences of some coagulation parameters in subgroup analysis were found, no clinically relevant alterations of the coagulation system in WD patients could be detected.
- Subjects
HEPATOLENTICULAR degeneration; METABOLISM; AUTOSOMAL recessive polycystic kidney; THROMBOPLASTIN; ANTITHROMBINS
- Publication
Journal of Gastrointestinal & Liver Diseases, 2015, Vol 24, Issue 2, p183
- ISSN
1841-8724
- Publication type
Article
- DOI
10.15403/jgld.2014.1121.242.wls