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- Title
Ziritaxestat and Lung Function in Idiopathic Pulmonary Fibrosis—Reply.
- Authors
Maher, Toby M.; Ford, Paul; Wijsenbeek, Marlies S.
- Abstract
The article discusses concerns about the ISABELA 1 and 2 clinical trials that tested ziritaxestat in idiopathic pulmonary fibrosis (IPF) patients, particularly highlighting unexpected outcomes in the placebo groups related to antifibrotic use and suggesting potential biases in future trials when antifibrotic agents are standard care, which could impact result interpretation and trial design.
- Subjects
IDIOPATHIC pulmonary fibrosis; PULMONARY fibrosis; LUNGS; CLINICAL trials
- Publication
JAMA: Journal of the American Medical Association, 2023, Vol 330, Issue 10, p973
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2023.12640