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- Title
Etomidat Sonrası Miyoklonusu Önlemede Farklı Magnezyum Sülfat Dozlarının Karşılaştırılması.
- Authors
Satılmış, Tülin; Güler, Aygün; Pamuk, Almıla Gülsün; Ayhan, Banu; Akıncı, Seda Banu; Sarıcaoğlu, Fatma; Çelebioğlu, Bilge; Aypar, Ülkü
- Abstract
Aim: Myoclonic movements are common problems during induction of anesthesia with etomidate. Magnesium sulfate has been shown to reduce myoclonus after etomidate induction. This study aimed to compare different doses of magnesium sulfate to prevent etomidate-induced myoclonus. Material and Methods: A prospective double-blind study was performed on 100 ASA I-III patients who were randomized into six groups. Magnesium sulfate in normal saline contained in coded 5 mL syringes was administered intravenously using the following dosages: Group I, 0 mg; Group II, 300 mg; Group III, 600 mg; Group IV, 900 mg; Group V, 1200 mg; Group VI, 1500 mg. Ninety and 150 seconds after pretreatment with these dosages, etomidate 0,2 mg kg-1 and vecuronium 0,1 mg kg-1 were injected, respectively. An anesthesiologist, blinded to the allocation of groups recorded myoclonic movements, pain, and sedation levels. Results: There were no significant differences between the groups with respect to age, body weight, gender, ASA physical status, types of the surgical operation performed, and comorbidities. Pretreatment with magnesium sulfate reduced the incidence and the severity of myoclonic movements after etomidate induction (P<0.05). Conclusion: Magnesium sulfate in dosages of 300 mg, 1200 mg, or 1500 mg administered 90 seconds before the induction of anaesthesia with etomidate is effective in reducing the severity of etomidate-induced myoclonus. We have concluded that the lowest dose (300 mg) of magnesium sulfate might be an alternative agent to prevent etomidate induced myoclonus.
- Subjects
MAGNESIUM sulfate; MYOCLONUS; ETOMIDATE; ANESTHESIA; CONSCIOUS sedation
- Publication
Journal of the Turkish Anaesthesiology & Intensive Care Society - JTAICS / Türk Anestezi ve Reanimasyon Dergisi, 2010, Vol 38, Issue 3, p184
- ISSN
1304-0871
- Publication type
Article