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- Title
Induction of apoptosis in HepG2 human hepatocellular carcinoma cells by a novel derivative of ursodeoxycholic acid (UDCA).
- Authors
Park, Yoo-Hoi; Kim, Jung-Ae; Baek, Jin-Hyen; Jung, Eun-Jin; Kim, Tae-Hyong; Suh, Hongsuk; Park, Myung-Hwan; Kim, Kyu-Won
- Abstract
The effects of ursodeoxycholic acid (UDCA) and its novel derivative, named as HS-1030, on the proliferation of HepG2, human hepatocellular carcinoma cells were investigated. Whereas UDCA had no significant effect in a concentration range we have tested, HS-1030 inhibited the proliferation of HepG2 cells in a concentration dependent manner. Surprisingly, HS-1030 had no effect on the proliferation of Human Chang liver cell which is a normal liver cell line. We also found that proliferation-inhibitory effect of HS-1030 was due to the induction of apoptosis of HepG2 cells, which was confirmed by observing the internucleosomal DNA fragmentation and morphological changes ( i.e. cell shrinkage, nuclear condensation and the formation of apoptotic bodies). These results suggest that HS-1030 may be a good candidate as a drug for the treatment of liver cancer.
- Publication
Archives of Pharmacal Research, 1997, Vol 20, Issue 1, p29
- ISSN
0253-6269
- Publication type
Article
- DOI
10.1007/BF02974038